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. 1975 Apr;3(4):195-9.

Experimental cerebral vasospasm in cats: modification by a new synthetic vasodilator YC-93

Y Handa, S Yoneda, T Koyama, M Matsuda, H Handa
  • PMID: 1145417

Experimental cerebral vasospasm in cats: modification by a new synthetic vasodilator YC-93

Y Handa et al. Surg Neurol. 1975 Apr.

Abstract

Effects of a new synthetic vasodilator, YC-93, a derivative of 1. 4-dihydropyridine, on experimental cerebral vasospasm, were studies in cats. A topical administration of YC-93 solution was found to rapidly reverse the spasm of the basilar artery induced with a subarachnoi application of fresh blood, serotonin or porstaglandin F2 alpha. Pretreatment of the basilar artery with YC-93 prevented the development of experimental vasospasm with all these agents.

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