Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer's disease-related cytoskeletal pathology

Abstract

The tegmentopontine reticular nucleus (nucleus of Bechterew) plays a crucial role in the generation of horizontal saccades and smooth pursuit movement of the eyes. The evolution of Alzheimer's disease-related cytoskeletal pathology was studied of this nucleus was studied in 27 autopsy cases at different stages of the cortical neurofibrillary pathology (NFT/NT stages I--VI). The first cytoskeletal changes were seen at stages I and II (preclinical Alzheimer's disease). At stages III and IV (incipient Alzheimer's disease), the nucleus exhibited a marked pathology, and it was severely involved at stages V and VI (clinically overt Alzheimer's disease). Damage to the tegmentopontine reticular nucleus most probably contributes to the hypometrie of horizontal saccades and the slowing of smooth pursuits that characteristically develop in patients suffering from Alzheimer's disease. Given the fact that pathological alterations of the tegmentopontine reticular nucleus begin early during the evolution of the underlying process, the question arises as to whether dysfunctional horizontal saccades and abnormal smooth pursuits could be employed as means of screening or diagnosing Alzheimer's patients in the very earliest stages of the disease.