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Editorial
. 2001 Aug;86(2):121-2.
doi: 10.1136/heart.86.2.121.

Homocysteine: a novel risk factor for coronary heart disease in UK Indian Asians

J C Chambers, J S Kooner
Editorial

Homocysteine: a novel risk factor for coronary heart disease in UK Indian Asians

J C Chambers et al. Heart. 2001 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Outline of metabolic pathway for homocysteine. (1) Transmethylation. Conversion of methionine to homocysteine, thereby transferring methyl group to other species (R). (2) Transsulfuration. Irreversible conversion of homocysteine to cysteine: via rate limiting enzyme cystathionine-β-synthase, with vitamin B6 as essential co-factor. (3) Remethylation. Regeneration of methionine from homocysteine: catabolised by methionine synthase, with 5,10-methylene-tetrahydrofolate (MTHF, a form of folic acid) and vitamin B12, as essential co-factors. (4) Regeneration of MTHF from tetrahydrofolate (THF), catabolised by enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR).
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