Review
doi: 10.1016/s0196-9781(01)00446-6.
Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates
Affiliations
- PMID: 11457515
- DOI: 10.1016/s0196-9781(01)00446-6
Item in Clipboard
Review
Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates
Peptides.
2001 Aug.
Abstract
The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCK(B)/D(2) receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.
Similar articles
-
Evidence for a differential cholecystokinin-B and -A receptor regulation of GABA release in the rat nucleus accumbens mediated via dopaminergic and cholinergic mechanisms.Neuroscience. 1996 Aug;73(4):941-50. doi: 10.1016/0306-4522(96)00098-x. Neuroscience. 1996. PMID: 8809813
-
Evidence for a nucleus accumbens CCK2 receptor regulation of rat ventral pallidal GABA levels: a dual probe microdialysis study.Life Sci. 2000 Dec 22;68(5):483-96. doi: 10.1016/s0024-3205(00)00949-8. Life Sci. 2000. PMID: 11197746
-
Cholecystokinin (CCK) increases GABA release in the rat anterior nucleus accumbens via CCK(B) receptors located on glutamatergic interneurons.Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):33-8. doi: 10.1007/s002109900161. Naunyn Schmiedebergs Arch Pharmacol. 2000. PMID: 10651144
-
Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides.Brain Res Rev. 2007 Aug;55(1):144-54. doi: 10.1016/j.brainresrev.2007.03.006. Epub 2007 Mar 24. Brain Res Rev. 2007. PMID: 17448541 Review.
-
What we know and what we need to know about the role of endogenous CCK in psychostimulant sensitization.Life Sci. 2003 Jun 27;73(6):643-54. doi: 10.1016/s0024-3205(03)00384-9. Life Sci. 2003. PMID: 12801586 Review.
Cited by
-
Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.BMC Neurosci. 2012 Jun 8;13:63. doi: 10.1186/1471-2202-13-63. BMC Neurosci. 2012. PMID: 22682150 Free PMC article.
-
A cholecystokinin B receptor antagonist and cocaine interaction, phase I study.CNS Neurosci Ther. 2019 Jan;25(1):136-146. doi: 10.1111/cns.12994. Epub 2018 Jun 20. CNS Neurosci Ther. 2019. PMID: 29923314 Free PMC article. Clinical Trial.
-
Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.PLoS One. 2013;8(1):e53643. doi: 10.1371/journal.pone.0053643. Epub 2013 Jan 14. PLoS One. 2013. PMID: 23341962 Free PMC article.
-
Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks.Front Physiol. 2012 Jun 4;3:136. doi: 10.3389/fphys.2012.00136. eCollection 2012. Front Physiol. 2012. PMID: 22675301 Free PMC article.
-
The biochemical bases of the placebo effect.Sci Eng Ethics. 2004 Jan;10(1):143-50. doi: 10.1007/s11948-004-0071-z. Sci Eng Ethics. 2004. PMID: 14986780 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
