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Review
. 2001 Aug;22(8):1229-34.
doi: 10.1016/s0196-9781(01)00446-6.

Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates

S Tanganelli  1 , K Fuxe, T Antonelli, W T O'Connor, L Ferraro
Affiliations
Review

Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates

S Tanganelli et al. Peptides. 2001 Aug.

Abstract

The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCK(B)/D(2) receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.

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