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Review

. 2001 Jul;108(2):165-7.

doi: 10.1172/JCI13560.

Heparan sulfate proteoglycans: intricate molecules with intriguing functions

R V Iozzo¹

Affiliations

Affiliation

¹ Department of Pathology, Anatomy and Cell Biology, and the Cellular Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. iozzo@lac.jci.tju.edu

PMID: 11457866
PMCID: PMC203034
DOI: 10.1172/JCI13560

Review

Heparan sulfate proteoglycans: intricate molecules with intriguing functions

R V Iozzo. J Clin Invest. 2001 Jul.

. 2001 Jul;108(2):165-7.

doi: 10.1172/JCI13560.

Author

R V Iozzo¹

Affiliation

¹ Department of Pathology, Anatomy and Cell Biology, and the Cellular Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. iozzo@lac.jci.tju.edu

PMID: 11457866
PMCID: PMC203034
DOI: 10.1172/JCI13560

No abstract available

PubMed Disclaimer

Figures

Figure 1
Schematic representation of the five HSPG prototypes. A total of thirteen distinct genes encompass nearly all the full-time HSPGs. These include four syndecans, six glypicans, and one each of perlecan, agrin, and the hybrid HSPG/collagen type XVIII. In addition, splice variants have been reported for perlecan, agrin, and type XVIII collagen. The size is roughly proportional to the number of amino acid residues (aa). The linear schemes do not take into account globular domains or other types of protein folding. The key to the various color-coded modules is provided in the bottom panel. The heparan sulfate chains are shown as wavy lines.

See this image and copyright information in PMC

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References

1. Iozzo RV. Matrix proteoglycans: from molecular design to cellular function. Annu Rev Biochem. 1998;67:609–652. - PubMed
1. Iozzo, R.V. 2000. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York, USA. 422 pp.
1. Bernfield M, et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem. 1999;68:729–777. - PubMed
1. Perrimon N, Bernfield M. Specificities of heparan sulphate proteoglycans in developmental processes. Nature. 2000;404:725–728. - PubMed
1. Lander AD, Selleck SB. The elusive functions of proteoglycans: in vivo veritas. J Cell Biol. 2000;148:227–232. - PMC - PubMed

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