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Comment
. 2001 Jul;108(2):181-3.
doi: 10.1172/JCI13508.

The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?

M P Vincenti  1 , C E Brinckerhoff
Affiliations
Comment

The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?

M P Vincenti et al. J Clin Invest. 2001 Jul.
No abstract available

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Figures

Figure 1
Figure 1
IL-1 activation of MAPK pathways. IL-1 binds to its cellular receptor and activates receptor-associated proteins (red), such as IRAK, TRAF6, and TAK1. The result is activation of several MAPK kinases (MKK6, MKK4, MKK7, and MEK1; green), which phosphorylate and active the MAPKs p38, JNK, and ERK (blue). SB203580 inhibits the p38 kinases, while PD98059 blocks activation of MEK1, and as a consequence ERK activation. SP600125 is a novel inhibitor of JNK, described by Han et al. in a recent issue of the JCI (13).
Figure 2
Figure 2
MAPK-inducible genes involved in inflammation and connective tissue breakdown. Activated MAPKs (blue) translocate to the nucleus, where they phosphorylate specific transcription factors (black), such as ATF2, c-Jun, Ets-1, c-Fos, and Elk-1. Activation of these transcription factors results in increased transcription from promoters of genes involved in inflammation and connective tissue disease, including those for c-jun, c-fos, and the MMPs.
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References

    1. Ruddy, S., Harris, E.D., Sledge, C.B., and Kelley, W.N. 2001. Kelley’s textbook of rheumatology. W.B. Saunders Co. Philadelphia, Pennsylvania, USA. 1904 pp.
    1. Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum. 1995;38:151–160. - PubMed
    1. Nagase H, Woessner JF., Jr Matrix metalloproteinases. J Biol Chem. 1999;274:21491–21494. - PubMed
    1. Vincenti MP. The matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) genes. Transcriptional and posttranscriptional regulation, signal transduction and cell-type-specific expression. Methods Mol Biol. 2001;151:121–148. - PubMed
    1. Auble DT, Brinckerhoff CE. The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts. Biochemistry. 1991;30:4629–4635. - PubMed

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