In vitro binding and pharmacokinetics of gold salts in plasma proteins and chelating agents
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In vitro binding and pharmacokinetics of gold salts in plasma proteins and chelating agents
J Rheumatol Suppl.
1979.
Abstract
The binding of sodium aurothiomalate, sodium aurothiosulphate and aurothioglucose to plasma proteins has been investigated in vitro. All gold compounds were bound to protein at a similar rate and had similar apparent affinity constants and binding capacities. Penicillamine (10 or 100 microgram/ml) was unable to chelate significant amounts of bound gold from plasma protein.
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