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. 1979:5:68-73.

In vitro binding and pharmacokinetics of gold salts in plasma proteins and chelating agents

D F Biggs, D M Boland, P Davis, J Wakaruk
  • PMID: 114650

In vitro binding and pharmacokinetics of gold salts in plasma proteins and chelating agents

D F Biggs et al. J Rheumatol Suppl. 1979.

Abstract

The binding of sodium aurothiomalate, sodium aurothiosulphate and aurothioglucose to plasma proteins has been investigated in vitro. All gold compounds were bound to protein at a similar rate and had similar apparent affinity constants and binding capacities. Penicillamine (10 or 100 microgram/ml) was unable to chelate significant amounts of bound gold from plasma protein.

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