Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Aug;39(8):2946-50.
doi: 10.1128/JCM.39.8.2946-2950.2001.

Detection of cervical infections in colposcopy clinic patients

S Lanham  1 , A Herbert, A Basarab, P Watt
Affiliations

Detection of cervical infections in colposcopy clinic patients

S Lanham et al. J Clin Microbiol. 2001 Aug.

Abstract

The purpose of this study was to determine if Neisseria gonorrhoeae; Chlamydia trachomatis; herpes simplex virus; cytomegalovirus; Epstein-Barr virus; human herpesviruses 6, 7, and 8; or adeno-associated virus influenced the production of cervical intraepithelial neoplasia. Two hundred thirty-one cervical smear samples were tested for the presence of the organisms by PCR. In addition, human papillomavirus types in the samples were determined by PCR and classified into cancer risk types of high, moderate, and low. There was no link with cervical intraepithelial neoplasia status and detection of herpes simplex virus, cytomegalovirus, Epstein-Barr virus, human herpesviruses 6 and 8, gonorrhea, or chlamydia. However, high-grade cervical intraepithelial neoplasia was found more frequently with mixed infection by moderate-risk human papillomavirus types and human herpesvirus 7 than with these papillomavirus types alone. The presence of human herpesvirus 7 may increase the oncogenic potential of moderate-risk human papillomavirus types.

PubMed Disclaimer

Figures

FIG. 1
FIG. 1
Incidence of cervical infections by age. Cervical specimens were tested for the pathogens shown, and the results are presented by patient age group. Hatched markings indicate mixed HPV infections.
FIG. 2
FIG. 2
The percentages of samples containing high-, moderate-, or low-risk HPV types with CIN 3 are shown. Within each HPV risk group, a distinction was made between the proportion of samples containing HHV-7 and those in which HHV-7 was not detected. For high-risk HPV types, the P value is 0.09; for moderate-risk HPV types, the P value is 0.016; and for low-risk HPV types, the P value is 0.3.
See this image and copyright information in PMC

References

    1. Berns K I. Parvoviridae: the viruses and their replication. In: Fields B N, Knipe D M, Howley P M, editors. Fields virology. 3rd ed. Philadelphia, Pa: Lippincott-Raven Publishers; 1996. pp. 2173–2197.
    1. Boyle D C M, Smith J R. Infection and cervical intraepithelial neoplasia. Int J Gynecol Cancer. 1999;9:177–186. - PubMed
    1. de Roda Husman A M, Walboomers J M M, van den Brule A J C, Meijer C J L M, Snijders P J F. The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol. 1995;76:1057–1062. - PubMed
    1. de Sanjosé S, Muñoz N, Bosch F X, Reimann K, Pedersen N S, Orfila J, Ascunce N, González L C, Tafur L, Gili M, Lette I, Viladiu P, Tormo M J, Moreo P, Shah K, Wahren B. Sexually transmitted agents and cervical neoplasia in Colombia and Spain. Int J Cancer. 1994;56:358–363. - PubMed
    1. Dewhurst S, MeIntyre K, Schnabel K, Hall C B. Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. J Clin Microbiol. 1993;31:416–418. - PMC - PubMed

Publication types

MeSH terms