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. 2001 Jul 27;293(5530):702-5.
doi: 10.1126/science.1061781.

Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A

J H Kabarowski  1 , K Zhu, L Q Le, O N Witte, Y Xu
Affiliations

Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A

J H Kabarowski et al. Science. .

Retraction in

  • Retraction.
    Witte ON, Kabarowski JH, Xu Y, Le LQ, Zhu K. Witte ON, et al. Science. 2005 Jan 14;307(5707):206. doi: 10.1126/science.307.5707.206b. Science. 2005. PMID: 15653487 No abstract available.

Abstract

Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to a specific cell-surface receptor. We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein-coupled receptor whose genetic ablation results in the development of autoimmunity. Activation of G2A by LPC increased intracellular calcium concentration, induced receptor internalization, activated ERK mitogen-activated protein kinase, and modified migratory responses of Jurkat T lymphocytes. This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis.

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