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. 1975 Apr;7(4):431-4.
doi: 10.1128/AAC.7.4.431.

Interactions of carbenicillin and ticarcillin with gentamicin

M Davies, J R Morgan, C Anand

Interactions of carbenicillin and ticarcillin with gentamicin

M Davies et al. Antimicrob Agents Chemother. 1975 Apr.

Abstract

The in vitro inactivation of gentamicin by carbenicillin and a new semisynthetic penicillin, ticarcillin (BRL 2288), has been demonstrated. Gentamicin half-lives have been studied in eight patients with end-stage renal failure, and a 25 to 74% reduction in half-life has resulted from the concomitant administration of therapeutic doses of carbenicillin and ticarcillin.

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