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. 1975 Jul;30(1):26-8.
doi: 10.1128/am.30.1.26-28.1975.

Emodin, a toxic metabolite of Aspergillus wentii isolated from weevil-damaged chestnuts

J M Wells, R J Cole, J W Kirksey

Emodin, a toxic metabolite of Aspergillus wentii isolated from weevil-damaged chestnuts

J M Wells et al. Appl Microbiol. 1975 Jul.

Abstract

A diarrheagenic toxin from culture extracts of Aspergillus wentii Wehmer isolated from weevil-damaged Chinese chestnuts was identified as emodin (2-methyl-4,5,7-trihydroxyanthraquinone). The orange-red, crystalline toxin (mp 255 to 257 C) showed ultraviolet absorption maxima in ethyl alcohol at 223, 250, 267, 290, and 442 nm, and infrared absorption maxima at 3,400 cm-1 (OH), 1,635, and 1,625 CM-1. Chemical shifts and coupling constants of the proton magnetic resonance spectra of the A. wentii toxin and of authentic emodin agreed. Mean lethal dose of emodin orally administered to 1-day-old DeKalb cockerels was 3.7 mg/kg.

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