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Review
. 2001 Jun;45(2):183-8.

PET imaging of hypoxia

J S Lewis  1 , M J Welch
Affiliations
  • PMID: 11476169
Review

PET imaging of hypoxia

J S Lewis et al. Q J Nucl Med. 2001 Jun.

Abstract

Hypoxia in tumors has been related to poor response to conventional therapies. This paper will discuss the methods, both invasive and non-invasive, used to determine hypoxia levels within tumors. PET imaging with two lead compounds 18F-fluoromisonidazole (18FMISO) and Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone (Cu-ATSM) and their relative effectiveness in delineating hypoxic regions will be discussed. The advantages of Cu-ATSM-PET over existing imaging agents will be discussed along with its potential application as a direct- and/or surrogate marker for the determination of oncological hypoxia in vivo.

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