Eosinophilic angiocentric fibrosis and Wegener's granulomatosis: a case report and literature review

Abstract

This report presents a case of eosinophilic angiocentric fibrosis in a man with Wegener's granulomatosis, the first report of a possible association between the two conditions. This association suggests a possible mechanism for its pathogenesis.

Figure 1 Established lesion of eosinophilic angiocentric fibrosis: perivascular fibrosis with obliteration of vessel lumens. Adjacent inflammatory infiltrate comprises eosinophils, lymphocytes, and plasma cells (haematoxylin and eosin).

Figure 2 The initial nasal biopsy demonstrating giant cells, numerous plasma cells, neutrophils, and occasional eosinophils (haematoxylin and eosin).