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. 1998 Nov;21(11):678-80.

[Change of hymodynamics and circulating endothelial cells in chronic obstructive pulmonary diseases (COPD) and cor pulmonale patients]

[Article in Chinese]
W Peng  1 , X Zou, B Mao
Affiliations
  • PMID: 11477897

[Change of hymodynamics and circulating endothelial cells in chronic obstructive pulmonary diseases (COPD) and cor pulmonale patients]

[Article in Chinese]
W Peng et al. Zhonghua Jie He He Hu Xi Za Zhi. 1998 Nov.

Abstract

Objective: To investigate the vascular endothelial injuries by observing the changes of circulating endothelial cells (CEC) numbers in blood and hemodynamics in COPD and cor pulmonale patients.

Method: The arterial catheterion technique and CEC collection technique were used, superoxide dismutase (SOD) and malondialdyhyde(MDA) levels were determined respectively.

Result: mPAP (3.76 +/- 0.75 kPa) and CEC (16.70 +/- 2.65/0.9 microliter), MDA (6.98 +/- 1.47 mumol/L) in the chronic cor pulmonale are higher than that of mPAP (2.09 +/- 0.41 kPa) and CEC (8.48 +/- 2.23 microliters) in COPD, the numbers of CEC are adversely correlated to PaO2 (gamma = 0.9423, P < 0.001) and positively correlated with mPAP (gamma = 0.8270, P < 0.001), superoxide dismutase(SOD) was decreased.

Conclusion: mPAP, CEC are higher in cor pulmonale than that in COPD, CEC numbers rise when the PaO2 was lowered, hypoxia may worsen the vascular endothelial injuries.

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