Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Feb;26(2):181-5.
doi: 10.1023/a:1011007131195.

Brain metabolic effects of acute nicotine

J W Pettegrew  1 , K Panchalingam, R J McClure, J Levine
Affiliations

Brain metabolic effects of acute nicotine

J W Pettegrew et al. Neurochem Res. 2001 Feb.

Abstract

(-)Nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. The behavioral rewards from (-)nicotine and perhaps addiction appear to be related to dopamine release. 31P NMR analysis reveals subcutaneously administered (-)nicotine produces acute alterations in brain membrane phospholipid and high-energy phosphate metabolism of Fischer 344 rats. These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Foot Ankle Int. 1999 Apr;20(4):258-62 - PubMed
    1. Neurobiol Aging. 1997 May-Jun;18(3):305-8 - PubMed
    1. J Neurochem. 1988 Apr;50(4):1243-7 - PubMed
    1. J Bioenerg Biomembr. 1993 Apr;25(2):153-63 - PubMed
    1. Pharmacology. 1998 Aug;57(2):104-16 - PubMed

Publication types

LinkOut - more resources