Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2001 Jul 31;98(16):8923-4.
doi: 10.1073/pnas.171326198.

Treasures in the attic: rolling circle transposons discovered in eukaryotic genomes

C Feschotte  1 , S R Wessler
Affiliations
Comment

Treasures in the attic: rolling circle transposons discovered in eukaryotic genomes

C Feschotte et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Structure of Helitron elements and the rolling circle transposition mechanism. (a) A generic Helitron showing sequences and structural features that may be cis requirements for transposition (see text for details). Helitrons from C. elegans contain a single gene whereas Helitrons from A. thaliana and O. sativa contain two or three. (b) A hypothetical mechanism for Helitron transposition and gene acquisition based on the proposed rolling circle mechanism for bacterial transposons (e.g., IS91; refs. and 18). The element (in red) could be either autonomous or nonautonomous. Two transposase molecules are shown (blue ellipses) cleaving at the donor and target sites and binding to the resulting 5′ ends. Replication at the cleaved donor site initiates at the free 3′ OH and proceeds to displace one strand of Helitron. If the palindrome and 3′ end of the element are recognized correctly, as is shown on the Left, cleavage occurs after the CTRR sequence and the one Helitron strand is transferred to the donor site where DNA replication resolves the heteroduplex. The illustration on the Right depicts one way by which DNA flanking the 3′ end of the element (in green) could be transferred along with the element to the donor site. This may be how Helitrons have acquired additional coding sequences.
See this image and copyright information in PMC

Comment on

  • Rolling-circle transposons in eukaryotes.
    Kapitonov VV, Jurka J. Kapitonov VV, et al. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8714-9. doi: 10.1073/pnas.151269298. Epub 2001 Jul 10. Proc Natl Acad Sci U S A. 2001. PMID: 11447285 Free PMC article.

References

    1. Britten R J, Graham D E, Neufeld B R. Methods Enzymol. 1974;29:323–405. - PubMed
    1. Goldberg R B. Biochem Genet. 1978;16:45–68. - PubMed
    1. International Human Genome Sequencing Consortium. Nature (London) 2001;409:860–921. - PubMed
    1. Kapitonov V V, Jurka J. Proc Natl Acad Sci USA. 2001;98:8714–8719. . (First Published July 10, 2001; 10.1073/pnas.151269298) - PMC - PubMed
    1. Mendiola M V, Bernales I, de la Cruz F. Proc Natl Acad Sci USA. 1994;91:1922–1926. - PMC - PubMed

Substances

LinkOut - more resources