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. 2001;25(3):159-61.
doi: 10.1007/s002640100240.

The prevalence of mycotoxins in Kashin-Beck disease

E Haubruge  1 , C Chasseur, C Debouck, F Begaux, C Suetens, F Mathieu, V Michel, C Gaspar, M Rooze, M Hinsenkamp, P Gillet, N Nolard, G Lognay
Affiliations

The prevalence of mycotoxins in Kashin-Beck disease

E Haubruge et al. Int Orthop. 2001.

Abstract
in English, French

Mycotoxins are naturally occurring toxic chemical compounds produced by fungi infesting agricultural crops both during their growth and storage. Such secondary metabolites, when ingested, can produce toxic syndromes in humans. As it has been suggested that mycotoxins might be involved in the development of Kashin-Beck disease (KBD), we undertook a survey of barley grains of KBD-affected families and non-affected families in that country. We found, by thin layer chromatography, a hitherto unknown metabolite of Alternaria sp. This was especially common on the barley grains of KBD-affected families.

Les mycotoxines sont des métabolites secondaires produits des champignons infestant les céréales au cours de la période culturale ou durant le stockage des grains. De telles substances chimiques peuvent être toxiques vis-à-vis de l'homme lorsqu'elle sont ingérées. La contamination des grains de céréales par des mycotoxines constitue toutefois une piste sérieuse pour la compréhension de l'étiologie de la maladie de Kashin-Beck. Nous avons entrepris des analyses de plusieurs mycotoxines sur des échantillons de grains d'orge provenant de familles malades et de familles non malades au Tibet. Un métabolite, encore inconnu, produit par Alternaria spp. a été détecté dans les échantillons de grains provenant des familles malades.

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