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. 1975 Apr;53(4):525-9.
doi: 10.1111/j.1476-5381.1975.tb07390.x.

An indirect sympathomimetic effect of burimamide on kitten isolated atria

A J Hood, J R Smy, D F Weetman

An indirect sympathomimetic effect of burimamide on kitten isolated atria

A J Hood et al. Br J Pharmacol. 1975 Apr.

Abstract

1. Burimamide (34-1080 muM) caused a concentration-dependent increase in the force and frequency of contraction of kitten isolated atria. 2. Metiamide (467 muM) had no stimulant action on kitten atria and did not modify the effects of burimamide. 3. The atrial stimulation produced by burimamide was reduced by (-)propranolol (34-68 nM) and by cocaine (3 muM). 4. The atrial stimulant effect of burimamide was prevented by pretreatment of kittens with reserpine (1 mg/kg, 24 h before the experiment). 5. It is concluded that burimamide causes atrial stimulation by releasing catecholamines.

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