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Clinical Trial
. 2001 Aug;52(2):210-2.
doi: 10.1046/j.0306-5251.2001.01432.x.

A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

G Rainer  1 , B Kiss, S Dallinger, O Findl, M Georgopoulos, C Vass, R Menapace, K Polak, H G Eichler, M Wolzt, L Schmetterer
Affiliations
Clinical Trial

A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

G Rainer et al. Br J Clin Pharmacol. 2001 Aug.

Abstract

Aims: To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients.

Methods: In a parallel group study nifedipine or placebo was administered for 3 months (n = 30). Ocular fundus pulsation amplitude (FPA), cup blood flow (Flowcup) and visual field mean deviation (MD) were measured.

Results: Five patients receiving nifedipine discontinued due to adverse events. Nifedipine did not affect FPA [difference: 0.3 microm (95% CI -0.3,0.9); P = 0.70], Flowcup: [difference: -9 rel.units (95% CI -133,114); P = 0.99], or MD [difference: 0.2dB (95% CI -2.2,2.7); P = 0.51] vs placebo.

Conclusions: Systemic nifedipine is not well tolerated in glaucoma patients and exerts no effect on visual fields or ocular perfusion.

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