doi: 10.1016/s0006-8993(01)02652-x.
Activation of spinal serotonin(2A/2C) receptors augments nociceptive responses in the rat
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- PMID: 11489268
- DOI: 10.1016/s0006-8993(01)02652-x
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Activation of spinal serotonin(2A/2C) receptors augments nociceptive responses in the rat
Brain Res.
.
Abstract
The role of spinal 5-HT(2A/2C) receptors in the regulation of spinal nociceptive transmission was studied. The 5-HT(2A/2C) agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the antagonist ketanserin tartrate were administered intrathecally immediately before the formalin test. Activation of spinal 5-HT(2A/2C) receptors increased the pain-like behavioural response in both the early and late phases. The findings support the hypothesis that spinal 5-HT(2A/2C) receptors augment the spinal afferent nociceptive impulses induced by peripheral inflammation.
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