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Comparative Study
. 2001 Aug;41(2):282-4.
doi: 10.1016/s0028-3908(01)00074-0.

Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors

C A Brady  1 , I M Stanford, I Ali, L Lin, J M Williams, A E Dubin, A G Hope, N M Barnes
Affiliations
Comparative Study

Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors

C A Brady et al. Neuropharmacology. 2001 Aug.

Abstract

The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor.

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