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. 1975 Jun-Jul;32(02):380-2.
doi: 10.1016/0014-2999(75)90309-x.

Blockade of reserpine emesis in pigeons by metoclopramide

R Coronas, L Pitarch, J Mallol

Blockade of reserpine emesis in pigeons by metoclopramide

R Coronas et al. Eur J Pharmacol. 1975 Jun-Jul.

Abstract

Reserpine (0.5 mg/kg i.m.) produced emesis in pigeons with 60% of the animals responding. Metoclopramide HCl at 10, 20 and 40 mg/kg p.o. administered 30 min before or after reserpine injection was effective in blocking reserpine emesis. Metoclopramide was unable to antagonize reserpine-induced sedation and hypotension in rats, thus inviting discussion of its possible mechanism in blocking reserpine emesis.

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