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. 2001 Aug;91(8):1258-63.
doi: 10.2105/ajph.91.8.1258.

Heart rate as a predictor of mortality: the MATISS project

F Seccareccia  1 , F Pannozzo, F Dima, A Minoprio, A Menditto, C Lo Noce, S Giampaoli; Malattie Cardiovascolari Aterosclerotiche Istituto Superiore di Sanita Project
Affiliations

Heart rate as a predictor of mortality: the MATISS project

F Seccareccia et al. Am J Public Health. 2001 Aug.

Abstract

Objectives: This study sought to verify the independent role of heart rate in the prediction of all-cause, cardiovascular, and noncardiovascular mortality in a low-risk male population.

Methods: In an Italian population-based observational study, heart rate was measured in 2533 men, aged 40 to 69 years, between 1984 and 1993. Data on cardiovascular risk factors were collected according to standardized procedures. Vital status was updated to December 1997.

Results: Of 2533 men followed up (representing 24,457 person-years), 393 men died. Age-adjusted death rates for 5 heart rate levels showed increasing trends. The adjusted hazard rate ratios for each heart rate increment were 1.52 (95% confidence interval [CI] = 1.29, 1.78) for all-cause mortality, 1.63 (95% CI = 1.26, 2.10) for cardiovascular mortality, and 1.47 (95% CI = 1.19, 1.80) for noncardiovascular mortality. Relative risks between extreme levels were more than 2-fold for all endpoints considered.

Conclusions: Heart rate is an independent predictor of cardiovascular, noncardiovascular, and total mortality in this Italian middle-aged male population.

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Figures

FIGURE 1—
FIGURE 1—
Map of Italy delineating the area covered by the MATISS Project.
FIGURE 2—
FIGURE 2—
All-cause, cardiovascular disease (CVD), and noncardiovascular (Non CVD) mortality risks as a function of heart rate levels among men aged 40–69 years: MATISS Project, 1984–1997.
See this image and copyright information in PMC

References

    1. Palatini P, Julius S. Heart rate and the cardiovascular risk. J Hypertens. 1997;15:3–17. - PubMed
    1. Palatini P, Julius S. Association of tachycardia with morbidity and mortality: pathophysiological considerations. J Hum Hypertens. 1997;11(suppl 1):S19–S27. - PubMed
    1. Palatini P, Casiglia E, Pauletto P, Staessen J, Kaciroti N, Julius S. Relationship of tachycardia with high blood pressure and metabolic abnormalities: a study with mixture analysis in three populations. Hypertension. 1997;30:1267–1273. - PubMed
    1. Wannamethee G, Shaper G. The association between heart rate and blood pressure, blood lipids and other cardiovascular risk factors. J Cardiovasc Risk. 1994;1:223–230. - PubMed
    1. Gillum RF. The epidemiology of resting heart rate in a national sample of men and women: associations with hypertension, coronary heart disease, blood pressure, and other cardiovascular risk factors. Am Heart J. 1988;116:163–174. - PubMed

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