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. 1975 Jun 19;28(2):153-8.
doi: 10.1007/BF00735748.

A mechanism of x chromosome aneuploidy in lymphocytes of aging women

P H Fitzgerald

A mechanism of x chromosome aneuploidy in lymphocytes of aging women

P H Fitzgerald. Humangenetik. .

Abstract

One and sometimes both X chromosomes in cultured lyphocytes of women donors showed division of the centromere when the centromeres of other chromosomes were entire. This premature centromere division (PCD) was associated with evidence of non-disjunction of the X chromosome. On average, 2% of metaphases from 32 women donors showed PCD, but the incidence was 4 times greater in women over 59 years of age than in women under 40 years. Increased X chromosome aneuploidy was associated with the higher frequency of PCD in cultured lymphocytes from older women. PCD of the X chromosome is considered to be the mechanism of non-disjunction causing the previously described aneuploidy in cultured lymphocytes of aging women.

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References

    1. Nature. 1961 Sep 16;191:1178-80 - PubMed
    1. Nature. 1963 Mar 16;197:1080-1 - PubMed
    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1964;8:439-52 - PubMed
    1. Nature. 1971 Sep 17;233(5316):191-3 - PubMed
    1. Clin Genet. 1972;3(3):169-79 - PubMed