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. 2000 Jun;14(2):145-7.

Determination of serum cytokines in individuals with HCV infection

X Fan  1 , W Liu, C Li
Affiliations
  • PMID: 11503046

Determination of serum cytokines in individuals with HCV infection

X Fan et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2000 Jun.

Abstract

Objective: To investigate the immunopathogenesis of chronic hepatitis C virus (HCV) infection.

Methods: Serum T-helper lymphocyte (Th1) cytokines (IFN-gamma, IL-2) and Th2 cytokines (IL-4, IL-10) were measured by ELISA in 18 individuals with chronic HCV infection 10 persons of chronic HBV infection and 11 normal persons.

Results: IL-2 (P <0.05), IL-4 and IL-10 (P <0.025, P <0.001) were significantly increased in HCV infected hosts as compared to 11 normal controls, the production of Th2 cytokines was more predominant.

Conclusions: An enhanced Th2 responses is present in HCV infection, which may he responsible for the chronicity of HCV infection.

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