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. 1975;25(2):95-105.
doi: 10.1159/000152714.

Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees

K Lange, R C Elston

Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees

K Lange et al. Hum Hered. 1975.

Abstract

A graph theoretic definition of pedigrees is given and a distinction drawn between simple and complex pedigrees. Algorithms are presented to calculate the likeihood of any kind of pedigree, assuming only segregation at a finite set of loci, nonassortative mating and no environmental correlations; multiple births and consanguineous marriages are explicity allowed for. The formulation given can lead to more powerful genetic counselling, segregation analysis and linkage analysis.

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