Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Jun;73(4):416-428.
doi: 10.1007/BF02994003.

The role of apoptosis in the pathogenesis of the myelodysplastic syndromes

Jane E Parker  1 , Ghulam J Mufti  2
Affiliations
Review

The role of apoptosis in the pathogenesis of the myelodysplastic syndromes

Jane E Parker et al. Int J Hematol. 2001 Jun.

Abstract

The paradoxical occurrence of peripheral cytopenias despite a normo/hypercellular marrow in myelodysplastic syndromes (MDS) has been attributed to excessive intramedullary hematopoietic cell apoptosis. It has also been postulated that abrogation of programmed cell death (PCD) may underlie MDS transformation to acute myeloid leukemia (AML). Despite overwhelming evidence for a role of aberrant apoptosis in myelodysplasia, the molecular mechanisms responsible for such changes have not been elucidated. This paper summarizes current evidence implicating a role for altered PCD in MDS and outlines potential cellular mechanisms whereby hematopoietic progenitor cell apoptosis may be dysregulated.

PubMed Disclaimer

References

    1. Leuk Lymphoma. 1997 Sep;27(1-2):111-8 - PubMed
    1. Science. 1995 Nov 17;270(5239):1189-92 - PubMed
    1. J Immunol. 1988 Oct 15;141(8):2629-34 - PubMed
    1. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8115-9 - PubMed
    1. Blood. 1996 Oct 1;88(7):2640-7 - PubMed