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Review
. 2001 Aug;26(8):504-10.
doi: 10.1016/s0968-0004(01)01908-9.

The glucose-regulated proteins: stress induction and clinical applications

A S Lee  1
Affiliations
Review

The glucose-regulated proteins: stress induction and clinical applications

A S Lee. Trends Biochem Sci. 2001 Aug.

Abstract

A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.

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