Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2001 Aug 14;98(17):9471-3.
doi: 10.1073/pnas.181353098.

Flotillas of lipid rafts fore and aft

L M Pierini  1 , F R Maxfield
Affiliations
Comment

Flotillas of lipid rafts fore and aft

L M Pierini et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
The plasma membranes of cells are composed of many types of submicroscopic disordered (yellow regions) and more ordered (all other regions) membrane domains, which are depicted here at much larger scale relative to the cells than their putative size. Ordered domains are resistant to solubilization by nonionic detergents and comprise a large fraction of the cell surface. In resting leukocytes (Left), all types of membrane domains, which are below the resolution of light microscopy, are evenly distributed around the cell periphery. Following stimulation (Right), two types of ordered membrane domains (or rafts) segregate to either pole of the cell, forming large assemblies (or flotillas), which can be easily visualized by light microscopy. For ease of illustration, these flotillas are shown as uniform patches of membrane. However, in actuality they are more likely to be composed of ordered domains intercalated with disordered ones. In T cells, the flotilla at the front of the cell (blue region) is marked by the ganglioside GM3, whereas the flotilla at the rear (green region) contains GM1. Fore and aft flotillas may also have other compositional differences in transmembrane proteins (e.g., CD44) and/or lipids (e.g., PIP2), which impart unique functions to each end of the cell.
See this image and copyright information in PMC

Comment on

References

    1. Gómez-Moutón C, Abad J L, Mira E, Lacalle R A, Gallardo E, Jimenez-Baranda S, Illa I, Bernad A, Manes S, Martinez-A C. Proc Natl Acad Sci USA. 2001;98:9642–9647. . (First Published August 7, 2001; 10.1073/pnas.171160298) - PMC - PubMed
    1. Brown D A, London E. Annu Rev Cell Dev Biol. 1998;14:111–136. - PubMed
    1. Simons K, Ikonen E. Nature (London) 1997;387:569–572. - PubMed
    1. Sheets E D, Holowka D, Baird B. Curr Opin Chem Biol. 1999;3:95–99. - PubMed
    1. Langlet C, Bernard A-M, Drevot P, He H-T. Curr Opin Immunol. 2000;12:250–255. - PubMed

LinkOut - more resources