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. 2001 Sep 14;293(5537):2111-4.
doi: 10.1126/science.1061964. Epub 2001 Aug 16.

An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway

B Schiemann  1 , J L Gommerman, K Vora, T G Cachero, S Shulga-Morskaya, M Dobles, E Frew, M L Scott
Affiliations

An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway

B Schiemann et al. Science. .

Abstract

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

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