Dichotomy in response to indomethacin in UV-C and UV-B induced ultraviolet light inflammation

Abstract

In subjects irradiated with both UV-C and UV-B ultraviolet light (UVL), 10 mug of intradermal indomethacin decreased the redness in all 13 of the UV-B irradiated areas but in only 2 of 13 of the UV-C irradiated areas. Higher doses of intradermal indomethacin (50 mug and 100 mug) decreased the redness produced by UV-C irradiation in 6 subjects. It is suggested that the failure of 10 mug of indomethacin to decrease the redness of the UV-C induced inflammation, while decreasing the redness in the UV-B induced inflammation, is consistent with the possibility that prostaglandins participate in UV-B but not UV-C induced inflammation.