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. 2001 Sep;45(3):387-91.
doi: 10.1067/mjd.2001.116217.

Natural course of physical and chronic urticaria and angioedema in 220 patients

M M Kozel  1 , J R Mekkes, P M Bossuyt, J D Bos
Affiliations

Natural course of physical and chronic urticaria and angioedema in 220 patients

M M Kozel et al. J Am Acad Dermatol. 2001 Sep.

Abstract

Background: Information about spontaneous remission of chronic urticaria is limited.

Objective: To investigate the natural course of urticaria, we followed up 220 adults in a prospective study.

Methods: Patients were followed up for 1 to 3 years to evaluate interventions, to detect latent causes, and to study the natural course of urticaria. The diagnosis was made by detailed history-taking as well as laboratory and provocation tests.

Results: Thirty-five percent of all patients were free of symptoms after 1 year. In 28.9% of patients, symptoms had decreased. Spontaneous remission occurred in 47.4% of the patients in whom no cause of their urticaria and/or angioedema could be identified and in only 16.4% of the patients with physical urticaria. A cause could be identified in 53.1% of the patients. Thirty-six percent of the patients had idiopathic urticaria. Chronic idiopathic urticaria combined with physical urticaria occurred in 10.9%.

Conclusion: In general, the prognosis for spontaneous remission is reasonable, with the exception of the subgroup (33.2%) with physical urticaria.

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Comment in

  • Fuzzy math.
    Weller R, Ha T. Weller R, et al. J Am Acad Dermatol. 2003 Oct;49(4):775; author reply 775. doi: 10.1067/s0190-9622(03)00075-6. J Am Acad Dermatol. 2003. PMID: 14512945 No abstract available.

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