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. 2001 Aug 20;11(16):2165-7.
doi: 10.1016/s0960-894x(01)00395-x.

N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors

P Madsen  1 , P Jakobsen, N Westergaard
Affiliations

N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors

P Madsen et al. Bioorg Med Chem Lett. .

Abstract

A novel class of N,N-dibenzyl-N'-benzylidenehydrazines as potent and competitive glucose-6-phosphatase catalytic site inhibitors are described. Optimisation of this series identified compounds with IC(50) values as low as 170 nM.

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