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. 2001 Aug 20;11(16):2185-8.
doi: 10.1016/s0960-894x(01)00407-3.

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

A Ali  1 , S D Aster, D W Graham, G F Patel, G E Taylor, R L Tolman, R E Painter, L L Silver, K Young, K Ellsworth, W Geissler, G S Harris
Affiliations

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

A Ali et al. Bioorg Med Chem Lett. .

Abstract

4-Substituted 2-amino-6-(anilino)pyrimidines have been found to be selective inhibitors of DNA polymerase III, a replicative enzyme known to be essential in the DNA synthesis of Gram-positive bacteria. Among the analogues, 18 displayed an IC(50) of 10 microM against DNA polymerase III from Staphylococcus aureus.

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