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. 2001 Jul;50(4):319-24.
doi: 10.1538/expanim.50.319.

Quantitative trait loci for body weight in the intercross between SM/J and A/J mice

R V Anunciado  1 , M Nishimura, M Mori, A Ishikawa, S Tanaka, F Horio, T Ohno, T Namikawa
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Free article

Quantitative trait loci for body weight in the intercross between SM/J and A/J mice

R V Anunciado et al. Exp Anim. 2001 Jul.
Free article

Abstract

We performed a genome-wide quantitative trait locus (QTL) analysis of body weight at 10 weeks of age in a population of 321 intercross offspring from SM/J and A/J mice, progenitor strains of SMXA recombinant inbred strains. Interval mapping revealed two significant QTLs, Bwq3 (body weight QTL3) and Bwq4, on Chromosomes (Chrs) 8 and 18 respectively, and five suggestive QTLs on Chrs 2, 6, 7, 15 and 19. Bwq3 and Bwq4 explained 6% of the phenotypic variance. The SM/J alleles at both QTLs increased body weight, though the SM/J mouse was smaller than the A/J mouse. On the other hand, four of the five suggestive QTLs detected had male-specific effects on body weight and the remainder was female-specific. These suggestive QTLs explained 5-6% of the phenotypic variance and all the SM/J alleles decreased body weight.

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