Comment
doi: 10.1016/s0960-9822(01)00360-8.
Wnt signalling: antagonistic Dickkopfs
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- PMID: 11516963
- DOI: 10.1016/s0960-9822(01)00360-8
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Comment
Wnt signalling: antagonistic Dickkopfs
Curr Biol.
.
Free article
Abstract
Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway.
Comment on
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Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.Curr Biol. 2000 Dec 14-28;10(24):1611-4. doi: 10.1016/s0960-9822(00)00868-x. Curr Biol. 2000. PMID: 11137016
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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.Curr Biol. 2001 Jun 26;11(12):951-61. doi: 10.1016/s0960-9822(01)00290-1. Curr Biol. 2001. PMID: 11448771
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