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Review
. 2001 Aug;108(4):497-501.
doi: 10.1172/JCI13712.

Glypicans: proteoglycans with a surprise

J Filmus  1 , S B Selleck
Affiliations
Review

Glypicans: proteoglycans with a surprise

J Filmus et al. J Clin Invest. 2001 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Schematic diagram of glypicans. GAG, glycosaminoglycan chains; GPI, glycosylphosphatidylinositol anchor.
Figure 2
Figure 2
Three phenotypes of Dally mutants. The top two panels show third instar larval brains stained with anti–Cyclin B antibody to reveal patterns of cell division (anterior to the left, dorsal up). The wild-type displays two bands of dividing cells that generate components of the visual system. One of these two sets of dividing cells is absent in dally mutants (arrows). The middle panels show scanning electron micrographs of a wild-type and an abnormal eye of a dpp/+; dally/+ transheterozygote. Both dpp and dally mutations are completely recessive, and the eye defects found in animals heterozygous for both mutations reveal a functional link between Dally, a Drosophila glypican, and decapentaplegic (Dpp), a homolog of bone morphogenetic protein 4. The bottom row shows wing margin notching and incomplete wing vein formation (arrowheads) associated with dally mutations. These defects are likely the result of defects in Wingless (a Wnt) and Dpp signaling, respectively.
See this image and copyright information in PMC

References

    1. Filmus, J., and Song, H.H. 2000. Glypicans. In Proteoglycans. R.V. Iozzo, editor. Marcel Dekker Inc. New York, New York, USA. 161–176.
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    1. Stipp CS, Litwac ED, Lander AD. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. J Cell Biol. 1994;124:149–160. - PMC - PubMed
    1. Filmus J, Church J, Buick RN. Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine. Mol Cell Biol. 1988;8:4243–4249. - PMC - PubMed
    1. Watanabe K, Yamada H, Yamaguchi Y. K-glypican: a novel GPI-linked heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995;130:1207–1218. - PMC - PubMed

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