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Clinical Trial
. 2001 Aug;185(2):485-6.
doi: 10.1067/mob.2001.115998.

Metronidazole treatment of women with a positive fetal fibronectin test result

R L Goldenberg  1 , M Klebanoff, J C Carey, C Macpherson
Affiliations
Clinical Trial

Metronidazole treatment of women with a positive fetal fibronectin test result

R L Goldenberg et al. Am J Obstet Gynecol. 2001 Aug.

Abstract

Eighty-nine women with either bacterial vaginosis, Trichomonas vaginalis, or both, who also had a positive fetal fibronectin test result were randomized to two courses of metronidazole treatment as part of a Maternal-Fetal Medicine Network Units study of the National Institute of Child Health and Human Development. In this subgroup analysis, compared with the placebo group, women who were treated with metronidazole had a nonsignificant reduction in spontaneous preterm birth from 14.6% to 8.3%.

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Comment in

  • Antimicrobials in the prevention of prematurity.
    Groom KM, Bennett PR, Poston L, Shennan AH. Groom KM, et al. Am J Obstet Gynecol. 2002 May;186(5):1106-7; author reply 1107. doi: 10.1067/mob.2002.122979. Am J Obstet Gynecol. 2002. PMID: 12015547 No abstract available.

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