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. 1975 Jun;18(6):604-7.
doi: 10.1021/jm00240a016.

Physiochemical-activity relations in practice. 1. A rational and self-consistent data bank

F E Norrington, R M Hyde, S G Williams, R Wootton

Physiochemical-activity relations in practice. 1. A rational and self-consistent data bank

F E Norrington et al. J Med Chem. 1975 Jun.

Abstract

A data bank of substituent constants of 26 ortho and 34 meta and para benzenoid substituents is presented for use in physicochemical-activity relations (PAR) studies. The distributive parameters pri and pri-, a bulk parameter based on molar refraction, and positionally weighted electronic parameters F and R are listed for the three substituent positions. There are no gaps in the table caused by missing values and the interparameter correlation are low.

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