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. 1975 Jun;18(6):619-21.
doi: 10.1021/jm00240a019.

Effect of 9-hydroxylation on benzomorphan antagonist activity

N F Albertson

Effect of 9-hydroxylation on benzomorphan antagonist activity

N F Albertson. J Med Chem. 1975 Jun.

Abstract

In a benzomorphan bearing an antagonist side chain, introduction on the methano bridge of a hydroxyl oriented away from nitrogen has little effect on antagonist activity whereas a hydroxyl oriented toward nitrogen enhances this activity. Hydroxylation tends to decrease analgesic activity.

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