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Comparative Study
. 2001 Apr;23(3):131-4.
doi: 10.1358/mf.2001.23.3.627945.

Effects of lisinopril on streptozotocin-induced diabetic neuropathy in rats

M Aggarwal  1 , J Singh, S Sood, B Arora
Affiliations
Free article
Comparative Study

Effects of lisinopril on streptozotocin-induced diabetic neuropathy in rats

M Aggarwal et al. Methods Find Exp Clin Pharmacol. 2001 Apr.
Free article

Abstract

Streptozotocin (STZ)-induced diabetic neuropathy in rats was monitored by measuring the motor nerve conduction velocity (MNCV) and histopathology of the tibial nerve. Pretreatment with lisinopril (2 mg/kg p.o., 5 days prior to STZ and continued for 10 weeks) significantly (p < 0.01) prevented deterioration of MNCV as compared to STZ-diabetic animals. Nerve sections from the lisinopril pretreated group revealed less structural damage as compared to STZ-diabetic rats. However lisinopril had no effect on blood sugar, i.e., it did not alter the diabetic state. It is concluded that lisinopril prevents the development of experimental diabetic neuropathy in STZ-induced diabetic rats.

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