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Clinical Trial
. 2001 Aug 28;57(4):731-3.
doi: 10.1212/wnl.57.4.731.

Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes"

M Filippi  1 , M Rovaris, M A Rocca, M P Sormani, J S Wolinsky, G Comi; Eurpoean/Canadian Glatiramer Acetate Study Group
Affiliations
Clinical Trial

Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes"

M Filippi et al. Neurology. .

Abstract

The authors evaluated whether glatiramer acetate (GA) modifies the severity of tissue damage in 1,722 new lesions from 239 patients with MS enrolled in a placebo-controlled trial monitored with monthly cerebral MRI. The percentage of new lesions that evolved into "black holes" was lower in GA-treated than in placebo patients on scans at 7 (18.9 and 26.3%; p = 0.04) and 8 (15.6 and 31.4%; p = 0.002) months after lesion appearance. GA has a favorable effect on tissue disruption in MS lesions once they are formed.

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