Relation between ulcerogenic activity of various NSAID and their potency as inhibitors of prostaglandin synthesis in vivo
- PMID: 115259
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Relation between ulcerogenic activity of various NSAID and their potency as inhibitors of prostaglandin synthesis in vivo
Agents Actions Suppl.
1979.
Abstract
A series of non-steroidal anti-inflammatory drugs (NSAID) and a few other agents were evaluated for their ability to: 1) reduce the acute toxicity of intravenously injected arachidonic acid (AA) in mice; 2) prevent castor oil-induced diarrhoea in mice; 3) enhance the formation of gastric mucosal erosions by a water stress in rats. A correlation between the activity in the three tests has been found for most NSAID studied, and the results point to inhibition of cyclooxygenase as a common mechanism of action.
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