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. 1979:(4):245-54.

Relation between ulcerogenic activity of various NSAID and their potency as inhibitors of prostaglandin synthesis in vivo

K M Strub, R K Müller
  • PMID: 115259

Relation between ulcerogenic activity of various NSAID and their potency as inhibitors of prostaglandin synthesis in vivo

K M Strub et al. Agents Actions Suppl. 1979.

Abstract

A series of non-steroidal anti-inflammatory drugs (NSAID) and a few other agents were evaluated for their ability to: 1) reduce the acute toxicity of intravenously injected arachidonic acid (AA) in mice; 2) prevent castor oil-induced diarrhoea in mice; 3) enhance the formation of gastric mucosal erosions by a water stress in rats. A correlation between the activity in the three tests has been found for most NSAID studied, and the results point to inhibition of cyclooxygenase as a common mechanism of action.

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