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. 2001 Sep;39(9):3200-3.
doi: 10.1128/JCM.39.9.3200-3203.2001.

Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant

E Alestig  1 , C Hannoun, P Horal, M Lindh
Affiliations

Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant

E Alestig et al. J Clin Microbiol. 2001 Sep.

Abstract

Mutations that prevent the expression of the hepatitis B e antigen frequently emerge in the immunoreactive phase of infection. The predominant mutation, the precore G-->A-1896 mutation, is restricted by the variability at position 1858 and is rare in strains with cytosine at nucleotide 1858. The C-1858 variant is characteristic of genotype A. It also occurs in genotypes C and F, but not in B, D, or E, explaining the geographical variation in the prevalence of precore mutants. C-1858 strains have been frequently observed in southeast Asia, but have not been phylogenetically characterized. By sequencing eight complete hepatitis B virus genomes, C-1858 variants of east Asian origin were found to constitute a phylogenetic entity within genotype C that probably diverged several hundred years ago. Further study of the distribution of this variant is warranted.

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Figures

FIG. 1
FIG. 1
Phylogenetic tree from distance matrix and neighbor-joining analysis of the complete HBV genome using the PAUP software. The analysis included the eight C-1858 strains (ea1 to ea8) and one T-1858 strain (975484), as well as 30 sequences obtained from the GenBank/EMBL/DDBJ databases (represented by their accession numbers). Bootstrap values are shown. Sequences with C-1858 are underlined.
FIG. 2
FIG. 2
SimPlot analysis comparing the C-1858 genotype C sequence AB031265 with sequences representing genotypes A, B, and C (including a consensus sequence of ea1 to ea8). The graph reveals recombination in AB031265 with a segment between nt 1260 and 1639 (indicated by arrows) originating from genotype B.
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