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Comparative Study
. 2001 Sep;39(9):3365-7.
doi: 10.1128/JCM.39.9.3365-3367.2001.

Cryptococcus neoformans var. neoformans (serotype D) strains are more susceptible to heat than C. neoformans var. grubii (serotype A) strains

L R Martinez  1 , J Garcia-Rivera, A Casadevall
Affiliations
Comparative Study

Cryptococcus neoformans var. neoformans (serotype D) strains are more susceptible to heat than C. neoformans var. grubii (serotype A) strains

L R Martinez et al. J Clin Microbiol. 2001 Sep.

Erratum in

  • J Clin Microbiol 2001 Nov;39(11):4224

Abstract

Cryptococcus neoformans var. neoformans (serotype D) and C. neoformans var. grubii (serotype A) differ in geographic prevalence and dermatotropism, with C. neoformans var. neoformans strains being more prevalent among isolates from temperate countries as well as from skin infections. Analysis of 19 strains from each serotype revealed wide variation in thermal susceptibility, with C. neoformans var. neoformans strains being more susceptible, on average, to heat killing. The results suggest a consistent explanation for the geographic differences between serotype A and D strains and for the dermatotropism of serotype D strains.

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Figures

FIG. 1
FIG. 1
Survival of serotype A (•) or D (▫). C. neoformans strains after exposure to 45°C (A) or 47°C (B) for 30 and 60 min. Solid and dashed lines denote mean and median values, respectively, for the distribution shown. This experiment was done twice with similar results.
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