Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Sep 3;11(17):2229-34.
doi: 10.1016/s0960-894x(01)00411-5.

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues

D W Ludovici  1 , R W Kavash, M J Kukla, C Y Ho, H Ye, B L De Corte, K Andries, M P de Béthune, H Azijn, R Pauwels, H E Moereels, J Heeres, L M Koymans, M R de Jonge, K J Van Aken, F F Daeyaert, P J Lewi, K Das, E Arnold, P A Janssen
Affiliations

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues

D W Ludovici et al. Bioorg Med Chem Lett. .

Abstract

A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.

PubMed Disclaimer

MeSH terms

LinkOut - more resources