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. 2001 Sep 3;11(17):2235-9.
doi: 10.1016/s0960-894x(01)00412-7.

Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues

D W Ludovici  1 , B L De Corte, M J Kukla, H Ye, C Y Ho, M A Lichtenstein, R W Kavash, K Andries, M P de Béthune, H Azijn, R Pauwels, P J Lewi, J Heeres, L M Koymans, M R de Jonge, K J Van Aken, F F Daeyaert, K Das, E Arnold, P A Janssen
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Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues

D W Ludovici et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.

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